- Edie Falco (Jackie Peyton)
- Merritt Wever (Zoey Barkow)
- Paul Schulze (Eddie Walzer)
- Dominic Fumusa (Kevin Peyton)
- Anna Deavere Smith (Gloria Akalitus)
- Stephen Wallem (Thor Lundgren)
- Betty Gilpin (Dr. Carrie Roman)
- Ruby Jerins (Grace Peyton)
- Mackenzie Aladjem (Fiona Peyton)
Nurse Jackie — S3E1
Episode: Game On
Air Date: 2011-03-28
Runtime: 30 min
Overview
In the Season 3 premiere, Jackie's marriage is strained, as is her relationship with O'Hara after the intervention; Akalitus warns the staff that nearby hospitals have closed down, straining the staff and resources; Zoey publicly confesses her affair with Lenny.