- Smriti Irani (Tulsi Virani)
- Amar Upadhyay (Mihir Virani)
- Tanisha Mehta (Vrinda Gokhale)
- Rohit Suchanti (Angad Virani)
- Shagun Sharma (Paridhi "Pari" Parekh(née Virani))
- Aman Gandhi (Hrithik Virani)
- Shakti Anand (Advocate Hemant Virani)
- Gauri Pradhan Tejwani (Nandini Virani)
- Ketki Dave (Daksha Virani)
- Apara Mehta (Savita Virani)
- Hiten Tejwani (Karan Virani)
- Ritu Chaudhary Seth (Shobha Virani)
- Kamalika Guha Thakurta (Gayatri Virani)
- Nirvaan Anandd (Ajay Parekh)
- Prachi Singh (Munni)
- Kunj Anand (Nitin Gokhale)
- Bhavna Rokade (Supriya Gokhale)
- Bharati Achrekar (Malti Parmeshwar Gokhale)
- Ankit Bhatia (Viren Mehta)
- Sanjivani Sathe (Indira Parekh)
- Shrashti Maheshwari (Sandhya Parekh)
- Amit Joshi (Priya Parekh)
- Barkha Bisht (Noina)
- Adhira Chavan (Child Paridhi "Pari" Virani)
Kyunki... Saas Bhi Kabhi Bahu Thi... — S2E221
Episode: Noina's Health Deteriorates
Air Date: 2026-03-06
Runtime: 28 min
Overview
The doctor reveals to Suchitra that Noina is suffering from cancer. Later, Tulsi worries and tells Mihir about Hrithik's decision to end his relationship with Mitali.