- Ellen Pompeo (Meredith Grey)
- Chandra Wilson (Miranda Bailey)
- James Pickens Jr. (Richard Webber)
- Caterina Scorsone (Amelia Shepherd)
- Camilla Luddington (Jo Wilson)
- Kevin McKidd (Owen Hunt)
- Kim Raver (Teddy Altman)
- Jason George (Ben Warren)
- Chris Carmack (Atticus Lincoln)
- Anthony Hill (Winston Ndugu)
- Adelaide Kane (Jules Millin)
- Alexis Floyd (Simone Griffith)
- Niko Terho (Lucas Adams)
- Harry Shum Jr. (Benson 'Blue' Kwan)
- Trevor Jackson (Wes Bryant)
Grey's Anatomy — S6E22
Episode: Shiny Happy People
Air Date: 2010-05-13
Runtime: 43 min
Overview
An elderly patient admitted into the E.R. for a heart condition sees a familiar face, a long lost love who happens to be in the E.R. as well for a fractured arm, and the staff find themselves caught up in their love story. Meanwhile, Karev treats a troubled teenage patient (guest star Demi Lovato) whose parents brought her in for schizophrenia, and Meredith can't help but tell Cristina about her suspicions of Owen -- which inevitably messes with Cristina's head.