- Ellen Pompeo (Meredith Grey)
- Chandra Wilson (Miranda Bailey)
- James Pickens Jr. (Richard Webber)
- Caterina Scorsone (Amelia Shepherd)
- Camilla Luddington (Jo Wilson)
- Kevin McKidd (Owen Hunt)
- Kim Raver (Teddy Altman)
- Jason George (Ben Warren)
- Chris Carmack (Atticus Lincoln)
- Anthony Hill (Winston Ndugu)
- Adelaide Kane (Jules Millin)
- Alexis Floyd (Simone Griffith)
- Niko Terho (Lucas Adams)
- Harry Shum Jr. (Benson 'Blue' Kwan)
- Trevor Jackson (Wes Bryant)
Grey's Anatomy — S4E16
Episode: Freedom (1)
Air Date: 2008-05-22
Runtime: 43 min
Overview
A couple undergoes surgery. Derek and Meredith's clinical trial gets a second shot from a new patient. Izzie helps Alex. McSteamy hooks up with someone.