- Minami Takayama (Conan Edogawa (voice))
- Kappei Yamaguchi (Shinichi Kudo (voice))
- Wakana Yamazaki (Ran Mouri (voice))
- Akemi Okamura (Ran Mouri (voice))
- Akira Kamiya (Kogoro Mouri (voice))
- Rikiya Koyama (Kogoro Mouri (voice))
- Megumi Hayashibara (Ai Haibara (voice))
- Kenichi Ogata (Hiroshi Agasa (voice))
- Yukiko Iwai (Ayumi Yoshida (voice))
- Wataru Takagi (Genta Kojima (voice))
- Ikue Otani (Mitsuhiko Tsuburaya (voice))
- Chafurin (Juzo Megure (voice))
Detective Conan — S1E496
Episode: Clash of Red and Black! (Invasion)
Air Date: 2008-02-18
Runtime: 25 min
Overview
The nurse tells Conan that she just remembered Eisuke had surgery for leukemia when he was young, raising the possibility Rena may in fact be his sister.