- Steven Weber (Dr. Dean Archer)
- Jessy Schram (Dr. Hannah Asher)
- Luke Mitchell (Dr. Mitchell 'Mitch' Ripley)
- Sarah Ramos (Dr. Caitlin Lenox)
- Darren Barnet (Dr. John Frost)
- S. Epatha Merkerson (Sharon Goodwin)
- Oliver Platt (Dr. Daniel Charles)
Episode: A Little Change Might Do You Some Good
Air Date: 2023-01-04
Runtime: 42 min
Charles and Cuevas help an elderly patient and her developmentally disabled grandson. Halstead treats a swimmer with a heart condition. Marcel considers using the OR 2.0 for surgery.