- Steven Weber (Dr. Dean Archer)
- Jessy Schram (Dr. Hannah Asher)
- Luke Mitchell (Dr. Mitchell 'Mitch' Ripley)
- Sarah Ramos (Dr. Caitlin Lenox)
- Darren Barnet (Dr. John Frost)
- S. Epatha Merkerson (Sharon Goodwin)
- Oliver Platt (Dr. Daniel Charles)
Episode: Pain Is for the Living
Air Date: 2020-02-05
Runtime: 42 min
Two brothers in critical condition are rushed into the hospital by their parents, leaving Dr. Choi, April and Dr. Charles to tend to their care and left to piece together what actually transpired. Dr. Manning becomes suspicious of a new mother entering the E.D. Dr. Halstead’s tireless activities at the safe injection site start to take a toll on his work.