- Steven Weber (Dr. Dean Archer)
- Jessy Schram (Dr. Hannah Asher)
- Luke Mitchell (Dr. Mitchell 'Mitch' Ripley)
- Sarah Ramos (Dr. Caitlin Lenox)
- Darren Barnet (Dr. John Frost)
- S. Epatha Merkerson (Sharon Goodwin)
- Oliver Platt (Dr. Daniel Charles)
Episode: Inheritance
Air Date: 2016-04-26
Runtime: 43 min
A teen patient with abdominal pain firmly refuses any drugs. Meanwhile, Dr. Halstead reconnects with his past when treating a patient; a pregnant woman does everything in her power not to deliver the child; and Dr. Rhodes tries to avoid family issues.