- Josh Charles (Dr. Martin Best)
- Abigail Spencer (Louisa Glasson)
- Josh Segarra (Sheriff Mark Mylow)
- Cree Cicchino (Elaine Denham)
- Annie Potts (Aunt Joan)
Best Medicine — S2E1
Episode: Be Careful What You Fish For
Air Date: 2026-09-22
Overview
While Martin continues to struggle with his blood phobia, a mermaid washes ashore in Port Wenn to the amazement of everyone in town. Meanwhile, Judith, a well-meaning townsperson (guest star Andrea Martin), creates havoc while on prescribed oxygen, Louisa continues to see Martin's girlfriend Eden for medical guidance and Greg and George's success from the seas urchin boom take its toll on the both of them.