NUMB3RS is a drama about an FBI agent who recruits his mathematical-genius brother to help the Bureau solve a wide range of challenging crimes in Los Angeles. The two brothers take on the most confounding criminal cases from a very distinctive perspective. Inspired by actual events, the series depicts how the confluence of police work and mathematics provides unexpected revelations and answers to the most perplexing criminal questions. A dedicated FBI agent, Don Eppes, couldn't be more different from his younger brother, Charlie Eppes, a brilliant mathematician who, since he was little, yearned to impress his big brother. Don is joined on his team by fellow agents David Sinclair, who utilizes his incredible perspective and the survival skills he learned growing up in the Bronx; Colby Granger, an Army veteran once stationed in the Middle East, who brings with him innovative methods to crime-solving; Liz Warner, a special agent who is also a former romantic interest of Don's; and newest agent Nikki Betancourt, a tough, street-smart ex-LAPD officer whose way of handling cases won't exactly mesh with how Don runs his team. Don and Charlie's father, Alan, is happy to see his sons working together even though he doesn't understand the intricacies of what Charlie does for a living. It is his co-workers at CalSci who further refine Charlie's approach and help him stay focused. Physicist friend Dr. Larry Fleinhardt constantly challenges Charlie to employ a broader point of view to his work with the FBI, and Amita Ramanjuan, Charlie's girlfriend and former grad student, frequently helps him see cases in a new light. Despite their disparate approaches to life, Don and Charlie are able to combine their areas of expertise and solve some killer cases.